Wnt5A and TGFβ1 Converges through YAP1 Activity and Integrin Alpha v Up-Regulation Promoting Epithelial to Mesenchymal Transition in Ovarian Cancer Cells and Mesothelial Cell Activation

Wnt5A and TGFβ1 Converges through YAP1 Activity and Integrin Alpha v Up-Regulation Promoting Epithelial to Mesenchymal Transition in Ovarian Cancer Cells and Mesothelial Cell Activation

In this paper, we investigate whether Wnt5A is associated with the TGF-β1/Smad2/3 and Hippo-YAP1/TAZ-TEAD pathways, implicated in epithelial to mesenchymal transition (EMT) in epithelial ovarian cancer. We used 3D and 2D cultures of human epithelial ovarian cancer cell lines SKOV-3, OVCAR-3, CAOV-4,...

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Bibliographic Details
Main Authors: Zeinab Dehghani-Ghobadi, Shahrzad Sheikh Hasani, Ehsan Arefian, Ghamartaj Hossein
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cells
Subjects:
epithelial to mesenchymal transition
ovarian cancer
Wnt5A
TGFβ1/Smad signaling
hippo-YAP1/TAZ signaling
integrin alpha v
Online Access:https://www.mdpi.com/2073-4409/11/2/237

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https://www.mdpi.com/2073-4409/11/2/237

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