Splicing-accessible coding 3′UTRs control protein stability and interaction networks

Splicing-accessible coding 3′UTRs control protein stability and interaction networks

Abstract Background 3′-Untranslated regions (3′UTRs) play crucial roles in mRNA metabolism, such as by controlling mRNA stability, translation efficiency, and localization. Intriguingly, in some genes the 3′UTR is longer than their coding regions, pointing to additional, unknown functions. Here, we...

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Bibliographic Details
Main Authors: Marco Preussner, Qingsong Gao, Eliot Morrison, Olga Herdt, Florian Finkernagel, Michael Schumann, Eberhard Krause, Christian Freund, Wei Chen, Florian Heyd
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Genome Biology
Subjects:
Alternative splicing
3′UTR
Protein stability
Protein disorder
Protein-protein interaction
Alternative open reading frame
Online Access:http://link.springer.com/article/10.1186/s13059-020-02102-3

Internet

http://link.springer.com/article/10.1186/s13059-020-02102-3

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