Tuberculosis Variant with Rifampin Resistance Undetectable by Xpert MTB/RIF, Botswana

Tuberculosis Variant with Rifampin Resistance Undetectable by Xpert MTB/RIF, Botswana

GeneXpert MTB/RIF, a tool widely used for diagnosing tuberculosis, has limitations for detecting rifampin resistance in certain variants. We report transmission of a pre–extensively drug-resistant variant in Botswana that went undetected by GeneXpert. The public health impact of misdiagnosis emphas...

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Bibliographic Details
Main Authors: Chawangwa Modongo, Ivan Barilar, Qiao Wang, Tuduetso Molefi, Topo Makhondo, Stefan Niemann, Sanghyuk S. Shin
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2023-11-01
Series:Emerging Infectious Diseases
Subjects:
multidrug-resistant tuberculosis
tuberculosis and other mycobacteria
pre–XDR TB
antimicrobial resistance
whole-genome sequencing
molecular diagnostics
Online Access:https://wwwnc.cdc.gov/eid/article/29/11/23-0987_article

Internet

https://wwwnc.cdc.gov/eid/article/29/11/23-0987_article

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