Synthesis of Phthalimide Derivatives as Potential PPAR-γ Ligands

Synthesis of Phthalimide Derivatives as Potential PPAR-γ Ligands

Paecilocin A, a phthalide derivative isolated from the jellyfish-derived fungus Paecilomyces variotii, activates PPAR-γ (Peroxisome proliferator-activated receptor gamma) in rat liver Ac2F cells. Based on a SAR (Structure-activity relationships) study and in silico analysis of paecilocin A-mimetic d...

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Bibliographic Details
Main Authors: So Hyeon Eom, Sen Liu, Mingzhi Su, Tae Hwan Noh, Jongki Hong, Nam Deuk Kim, Hae Young Chung, Min Hye Yang, Jee H. Jung
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:Marine Drugs
Subjects:
PPAR-γ agonist
paecilocin A
type 2 diabetes
phthalimide
adipogenesis
3T3-L1
Online Access:http://www.mdpi.com/1660-3397/14/6/112

Internet

http://www.mdpi.com/1660-3397/14/6/112

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