5-Methoxyflavone alleviates LPS-mediated lung injury by promoting Nrf2-mediated the suppression of NOX4/TLR4 axis in bronchial epithelial cells and M1 polarization in macrophages

5-Methoxyflavone alleviates LPS-mediated lung injury by promoting Nrf2-mediated the suppression of NOX4/TLR4 axis in bronchial epithelial cells and M1 polarization in macrophages

Abstract Background Acute lung injury (ALI) arises from sepsis or bacterial infection, which are life-threatening respiratory disorders that cause the leading cause of death worldwide. 5-Methoxyflavone, a methylated flavonoid, is gaining increased attention for its various health benefits. In the cu...

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Bibliographic Details
Main Authors: Panqiao Liang, Linxin Wang, Sushan Yang, Xiping Pan, Jiashun Li, Yuehan Zhang, Yueyun Liang, Jing Li, Beixian Zhou
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Journal of Inflammation
Subjects:
Methylated flavonoid
5-Methoxyflavone
Nrf2
LPS
Acute lung injury
Online Access:https://doi.org/10.1186/s12950-022-00319-6

Internet

https://doi.org/10.1186/s12950-022-00319-6

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