Postischemic Infusion of Apigenin Reduces Seizure Burden in Preterm Fetal Sheep

Postischemic Infusion of Apigenin Reduces Seizure Burden in Preterm Fetal Sheep

Seizures are common in preterm newborns and are associated with poor neurodevelopmental outcomes. Current anticonvulsants have poor efficacy, and many have been associated with upregulation of apoptosis in the developing brain. Apigenin, a natural bioactive flavonoid, is a potent inhibitor of hyalur...

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Bibliographic Details
Main Authors: Kenta H. T. Cho, Natalya Hounsell, Evelyn McClendon, Art Riddle, Basappa, Simerdeep K. Dhillon, Laura Bennet, Stephen Back, Larry S. Sherman, Alistair J. Gunn, Justin M. Dean
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
hypoxic–ischemic encephalopathy
seizures
anticonvulsants
apigenin
extracellular matrix
hyaluronidase
Online Access:https://www.mdpi.com/1422-0067/24/23/16926

Internet

https://www.mdpi.com/1422-0067/24/23/16926

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