Nanoparticle-Delivered Transforming Growth Factor-β1 siRNA Induces PD-1 against Gastric Cancer by Transforming the Phenotype of the Tumor Immune Microenvironment

Nanoparticle-Delivered Transforming Growth Factor-β1 siRNA Induces PD-1 against Gastric Cancer by Transforming the Phenotype of the Tumor Immune Microenvironment

Immune checkpoint blockade (ICB) is currently considered to be an important therapeutic method, which obtained FDA approval for clinical use in gastric cancer in 2017. As a new mechanism, it was found that the effect of αPDL1 could be improved by blocking the TGF-β1 signaling pathway, which converts...

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Bibliographic Details
Main Authors: Fenglei Wu, Xiujuan Xu, Wei Li, Yidong Hong, Huan Lai, Jingzhou Zhang, Xueyu Wu, Kangjie Zhou, Nan Hu
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Pharmaceuticals
Subjects:
nanoparticle
gastric cancer
tumor microenvironment
immunotherapy
Online Access:https://www.mdpi.com/1424-8247/15/12/1487

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https://www.mdpi.com/1424-8247/15/12/1487

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