Interplay of early negative life events, development of orbitofrontal cortical thickness and depression in young adulthood

Interplay of early negative life events, development of orbitofrontal cortical thickness and depression in young adulthood

Abstract Background Early negative life events (NLE) have long‐lasting influences on neurodevelopment and psychopathology. Reduced orbitofrontal cortex (OFC) thickness was frequently associated with NLE and depressive symptoms. OFC thinning might mediate the effect of NLE on depressive symptoms, alt...

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Bibliographic Details
Main Authors: Lea L. Backhausen, Jonas Granzow, Juliane H. Fröhner, Eric Artiges, Marie‐Laure Paillère‐Martinot, Hervé Lemaître, Fabio Sticca, Tobias Banaschewski, Sylvane Desrivières, Antoine Grigis, Andreas Heinz, Rüdiger Brühl, Dimitri Papadopoulos‐Orfanos, Luise Poustka, Sarah Hohmann, Lauren Robinson, Henrik Walter, Jeanne Winterer, Gunter Schumann, Jean‐Luc Martinot, Michael N. Smolka, Nora C. Vetter, the IMAGEN Consortium
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:JCPP Advances
Subjects:
adolescence
depression
life events
longitudinal studies
structural MRI (sMRI)
Online Access:https://doi.org/10.1002/jcv2.12210

Internet

https://doi.org/10.1002/jcv2.12210

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