Antioxidant Properties and Aldehyde Reactivity of PD-L1 Targeted Aryl-Pyrazolone Anticancer Agents

Antioxidant Properties and Aldehyde Reactivity of PD-L1 Targeted Aryl-Pyrazolone Anticancer Agents

Small molecules targeting the PD-1/PD-L1 checkpoint are actively searched to complement the anticancer arsenal. Different molecular scaffolds have been reported, including phenyl-pyrazolone derivatives which potently inhibit binding of PD-L1 to PD-1. These molecules are structurally close to antioxi...

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Bibliographic Details
Main Authors: Natascha Leleu-Chavain, Romain Regnault, Hania Ahouari, Raphaël Le Biannic, Mostafa Kouach, Frédérique Klupsch, Romain Magnez, Hervé Vezin, Xavier Thuru, Christian Bailly, Jean-François Goossens, Régis Millet
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
Subjects:
aldehyde reactivity
antioxidant
cancer
drug adducts
edaravone
PD-L1
Online Access:https://www.mdpi.com/1420-3049/27/10/3316

Internet

https://www.mdpi.com/1420-3049/27/10/3316

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