Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation

Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation

Abstract In mammals, global passive demethylation contributes to epigenetic reprogramming during early embryonic development. At this stage, the majority of DNA-methyltransferase 1 (DNMT1) protein is excluded from nucleus, which is considered the primary cause. However, whether the remaining nuclear...

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Bibliographic Details
Main Authors: Jiajun Tan, Yingfeng Li, Xiang Li, Xiaoxiao Zhu, Liping Liu, Hua Huang, Jiahua Wei, Hailing Wang, Yong Tian, Zhigao Wang, Zhuqiang Zhang, Bing Zhu
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-51614-0

Internet

https://doi.org/10.1038/s41467-024-51614-0

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