The effects of capillary transit time heterogeneity (CTH) on the cerebral uptake of glucose and glucose analogs:Application to FDG and comparison to oxygen uptake.

Glucose is the brain’s principal source of ATP, but the extent to which cerebral glucose consumption (CMRglc) is coupled with its oxygen consumption (CMRO2) remains unclear. Measurements of the brain’s oxygen-glucose index OGI=CMRO2/CMRglc suggest that its oxygen uptake largely suffices for oxidativ...

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Bibliographic Details
Main Authors: Hugo Angleys, Sune Nørhøj Jespersen, Leif Østergaard
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Computational Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncom.2016.00103/full