LNK promotes the growth and metastasis of triple negative breast cancer via activating JAK/STAT3 and ERK1/2 pathway

Abstract Background LNK adaptor protein is a crucial regulator of normal hematopoiesis, which down-regulates activated tyrosine kinases at the cell surface resulting in an antitumor effect. To date, little studies have examined activities of LNK in solid tumors except ovarian cancer. Methods Clinica...

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Bibliographic Details
Main Authors: Jianxin Lv, Wei Yu, Yanan Zhang, Xinhua Cao, Lifei Han, Haolin Hu, Chenfei Wang
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Cancer Cell International
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12935-020-01197-9