PPARα Agonist Suppresses Inflammation after Corneal Alkali Burn by Suppressing Proinflammatory Cytokines, MCP-1, and Nuclear Translocation of NF-κB

PPARα Agonist Suppresses Inflammation after Corneal Alkali Burn by Suppressing Proinflammatory Cytokines, MCP-1, and Nuclear Translocation of NF-κB

We investigated the effect of a peroxisome proliferator-activated receptor α (PPARα) agonist after corneal alkali injury. Fenofibrate 0.05% (PPARα agonist group) or vehicle (Vehicle group) was topically instilled onto the rat cornea after injury. Histological, immunohis...

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Bibliographic Details
Main Authors: Yuichiro Nakano, Masaaki Uchiyama, Takeshi Arima, Shinya Nagasaka, Tsutomu Igarashi, Akira Shimizu, Hiroshi Takahashi
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Molecules
Subjects:
fenofibrate
IκB-α
IL-1β
ophthalmic solution
VEGF-A
Online Access:http://www.mdpi.com/1420-3049/24/1/114

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http://www.mdpi.com/1420-3049/24/1/114

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