Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures

Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures

Genetic variants identified by genome-wide association studies explain only a modest proportion of heritability, suggesting that meaningful associations lie 'hidden' below current thresholds. Here, we integrate information from association studies with epigenomic maps to demonstrate that e...

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Bibliographic Details
Main Authors: Xinchen Wang, Nathan R Tucker, Gizem Rizki, Robert Mills, Peter HL Krijger, Elzo de Wit, Vidya Subramanian, Eric Bartell, Xinh-Xinh Nguyen, Jiangchuan Ye, Jordan Leyton-Mange, Elena V Dolmatova, Pim van der Harst, Wouter de Laat, Patrick T Ellinor, Christopher Newton-Cheh, David J Milan, Manolis Kellis, Laurie A Boyer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-05-01
Series:eLife
Subjects:
genome-wide association study
epigenomics
heritability
enhancer
complex trait
Online Access:https://elifesciences.org/articles/10557

Internet

https://elifesciences.org/articles/10557

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