Host Pah1p phosphatidate phosphatase limits viral replication by regulating phospholipid synthesis.

Host Pah1p phosphatidate phosphatase limits viral replication by regulating phospholipid synthesis.

Replication of positive-strand RNA viruses [(+)RNA viruses] takes place in membrane-bound viral replication complexes (VRCs). Formation of VRCs requires virus-mediated manipulation of cellular lipid synthesis. Here, we report significantly enhanced brome mosaic virus (BMV) replication and much impro...

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Bibliographic Details
Main Authors: Zhenlu Zhang, Guijuan He, Gil-Soo Han, Jiantao Zhang, Nicholas Catanzaro, Arturo Diaz, Zujian Wu, George M Carman, Lianhui Xie, Xiaofeng Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1006988

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https://doi.org/10.1371/journal.ppat.1006988

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