Induction of Innate Immune Response by TLR3 Agonist Protects Mice against SARS-CoV-2 Infection

Induction of Innate Immune Response by TLR3 Agonist Protects Mice against SARS-CoV-2 Infection

SARS-CoV-2, a member of the coronavirus family, is the causative agent of the COVID-19 pandemic. Currently, there is still an urgent need in developing an efficient therapeutic intervention. In this study, we aimed at evaluating the therapeutic effect of a single intranasal treatment of the TLR3/MDA...

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Bibliographic Details
Main Authors: Hadas Tamir, Sharon Melamed, Noam Erez, Boaz Politi, Yfat Yahalom-Ronen, Hagit Achdout, Shlomi Lazar, Hila Gutman, Roy Avraham, Shay Weiss, Nir Paran, Tomer Israely
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Viruses
Subjects:
SARS-CoV-2
COVID-19
hACE2-K18 transgenic mice
TLR3
Poly(I:C)
innate immune response
Online Access:https://www.mdpi.com/1999-4915/14/2/189

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https://www.mdpi.com/1999-4915/14/2/189

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