Activation of a7 Nicotinic Acetylcholine Receptors Prevents Monosodium Iodoacetate-Induced Osteoarthritis in Rats

Activation of a7 Nicotinic Acetylcholine Receptors Prevents Monosodium Iodoacetate-Induced Osteoarthritis in Rats

Background/Aims: Although some evidence suggests that the prevalence of osteoarthritis (OA) is lower in smokers compared to nonsmokers, the mechanisms of nicotine-induced protection remain unclear. Stimulation of the a7 nicotinic acetylcholine receptor (a7-nAChR) appears to be a critical mechanism u...

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Bibliographic Details
Main Authors: Yuan Liu, Dongying Wu, Fanglong Song, Chenlei Zhu, Yujian Hui, Qingcheng Zhu, Jie Wu, Weimin Fan, Jun Hu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-01-01
Series:Cellular Physiology and Biochemistry
Subjects:
Monosodium iodoacetate
Chondrocyte
Rat
Osteoarthritis
Nicotinic acetylcholine receptor
Online Access:http://www.karger.com/Article/FullText/369724

Internet

http://www.karger.com/Article/FullText/369724

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