Gold coordination during homogeneous alkyne and allene cyclisation catalysis: Coordination to substrates, to ancillary ligands and in intermediates
The ever-increasing role of homogeneous gold catalysis in organic synthesis and the consequent need to be able to rationally control the rate and outcome of such reactions has emphasised the importance of each successive metal–carbon coordination step. Concentrating on alkyne and allene cyclisation...
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Format: | Article |
Language: | English |
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Academy of Science of South Africa
2011-03-01
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Series: | South African Journal of Science |
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Online Access: | http://archive.sajs.co.za/index.php/SAJS/article/view/459 |
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author | Helgard G. Raubenheimer Hubert Schmidbaur |
author_facet | Helgard G. Raubenheimer Hubert Schmidbaur |
author_sort | Helgard G. Raubenheimer |
collection | DOAJ |
description | The ever-increasing role of homogeneous gold catalysis in organic synthesis and the consequent need to be able to rationally control the rate and outcome of such reactions has emphasised the importance of each successive metal–carbon coordination step. Concentrating on alkyne and allene cyclisation and upon reaction mechanisms postulated on the basis of empirical and theoretical results, we have examined the coordination of gold fragments to triple bonds, the modification of gold(I) precatalysts to effect specific reaction pathways or enantioselectivity and the isolation of coordinated intermediates or model compounds thereof. Some of the recent advances that have been made in various laboratories are described in this compact review. |
first_indexed | 2024-12-19T18:21:00Z |
format | Article |
id | doaj.art-222804b35e1e4e45a7908c499badf088 |
institution | Directory Open Access Journal |
issn | 0038-2353 1996-7489 |
language | English |
last_indexed | 2024-12-19T18:21:00Z |
publishDate | 2011-03-01 |
publisher | Academy of Science of South Africa |
record_format | Article |
series | South African Journal of Science |
spelling | doaj.art-222804b35e1e4e45a7908c499badf0882022-12-21T20:10:59ZengAcademy of Science of South AfricaSouth African Journal of Science0038-23531996-74892011-03-011073/410.4102/sajs.v107i3/4.459459Gold coordination during homogeneous alkyne and allene cyclisation catalysis: Coordination to substrates, to ancillary ligands and in intermediatesHelgard G. Raubenheimer0Hubert Schmidbaur1Stellenbosch UniversityTechnische Universität MünchenThe ever-increasing role of homogeneous gold catalysis in organic synthesis and the consequent need to be able to rationally control the rate and outcome of such reactions has emphasised the importance of each successive metal–carbon coordination step. Concentrating on alkyne and allene cyclisation and upon reaction mechanisms postulated on the basis of empirical and theoretical results, we have examined the coordination of gold fragments to triple bonds, the modification of gold(I) precatalysts to effect specific reaction pathways or enantioselectivity and the isolation of coordinated intermediates or model compounds thereof. Some of the recent advances that have been made in various laboratories are described in this compact review.http://archive.sajs.co.za/index.php/SAJS/article/view/459gold catalystsgold complex intermediateshomogeneous catalysismechanistic studiesorganic synthesis |
spellingShingle | Helgard G. Raubenheimer Hubert Schmidbaur Gold coordination during homogeneous alkyne and allene cyclisation catalysis: Coordination to substrates, to ancillary ligands and in intermediates South African Journal of Science gold catalysts gold complex intermediates homogeneous catalysis mechanistic studies organic synthesis |
title | Gold coordination during homogeneous alkyne and allene cyclisation catalysis: Coordination to substrates, to ancillary ligands and in intermediates |
title_full | Gold coordination during homogeneous alkyne and allene cyclisation catalysis: Coordination to substrates, to ancillary ligands and in intermediates |
title_fullStr | Gold coordination during homogeneous alkyne and allene cyclisation catalysis: Coordination to substrates, to ancillary ligands and in intermediates |
title_full_unstemmed | Gold coordination during homogeneous alkyne and allene cyclisation catalysis: Coordination to substrates, to ancillary ligands and in intermediates |
title_short | Gold coordination during homogeneous alkyne and allene cyclisation catalysis: Coordination to substrates, to ancillary ligands and in intermediates |
title_sort | gold coordination during homogeneous alkyne and allene cyclisation catalysis coordination to substrates to ancillary ligands and in intermediates |
topic | gold catalysts gold complex intermediates homogeneous catalysis mechanistic studies organic synthesis |
url | http://archive.sajs.co.za/index.php/SAJS/article/view/459 |
work_keys_str_mv | AT helgardgraubenheimer goldcoordinationduringhomogeneousalkyneandallenecyclisationcatalysiscoordinationtosubstratestoancillaryligandsandinintermediates AT hubertschmidbaur goldcoordinationduringhomogeneousalkyneandallenecyclisationcatalysiscoordinationtosubstratestoancillaryligandsandinintermediates |