Gold coordination during homogeneous alkyne and allene cyclisation catalysis: Coordination to substrates, to ancillary ligands and in intermediates

The ever-increasing role of homogeneous gold catalysis in organic synthesis and the consequent need to be able to rationally control the rate and outcome of such reactions has emphasised the importance of each successive metal–carbon coordination step. Concentrating on alkyne and allene cyclisation...

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Main Authors: Helgard G. Raubenheimer, Hubert Schmidbaur
Format: Article
Language:English
Published: Academy of Science of South Africa 2011-03-01
Series:South African Journal of Science
Subjects:
Online Access:http://archive.sajs.co.za/index.php/SAJS/article/view/459
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author Helgard G. Raubenheimer
Hubert Schmidbaur
author_facet Helgard G. Raubenheimer
Hubert Schmidbaur
author_sort Helgard G. Raubenheimer
collection DOAJ
description The ever-increasing role of homogeneous gold catalysis in organic synthesis and the consequent need to be able to rationally control the rate and outcome of such reactions has emphasised the importance of each successive metal–carbon coordination step. Concentrating on alkyne and allene cyclisation and upon reaction mechanisms postulated on the basis of empirical and theoretical results, we have examined the coordination of gold fragments to triple bonds, the modification of gold(I) precatalysts to effect specific reaction pathways or enantioselectivity and the isolation of coordinated intermediates or model compounds thereof. Some of the recent advances that have been made in various laboratories are described in this compact review.
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spelling doaj.art-222804b35e1e4e45a7908c499badf0882022-12-21T20:10:59ZengAcademy of Science of South AfricaSouth African Journal of Science0038-23531996-74892011-03-011073/410.4102/sajs.v107i3/4.459459Gold coordination during homogeneous alkyne and allene cyclisation catalysis: Coordination to substrates, to ancillary ligands and in intermediatesHelgard G. Raubenheimer0Hubert Schmidbaur1Stellenbosch UniversityTechnische Universität MünchenThe ever-increasing role of homogeneous gold catalysis in organic synthesis and the consequent need to be able to rationally control the rate and outcome of such reactions has emphasised the importance of each successive metal–carbon coordination step. Concentrating on alkyne and allene cyclisation and upon reaction mechanisms postulated on the basis of empirical and theoretical results, we have examined the coordination of gold fragments to triple bonds, the modification of gold(I) precatalysts to effect specific reaction pathways or enantioselectivity and the isolation of coordinated intermediates or model compounds thereof. Some of the recent advances that have been made in various laboratories are described in this compact review.http://archive.sajs.co.za/index.php/SAJS/article/view/459gold catalystsgold complex intermediateshomogeneous catalysismechanistic studiesorganic synthesis
spellingShingle Helgard G. Raubenheimer
Hubert Schmidbaur
Gold coordination during homogeneous alkyne and allene cyclisation catalysis: Coordination to substrates, to ancillary ligands and in intermediates
South African Journal of Science
gold catalysts
gold complex intermediates
homogeneous catalysis
mechanistic studies
organic synthesis
title Gold coordination during homogeneous alkyne and allene cyclisation catalysis: Coordination to substrates, to ancillary ligands and in intermediates
title_full Gold coordination during homogeneous alkyne and allene cyclisation catalysis: Coordination to substrates, to ancillary ligands and in intermediates
title_fullStr Gold coordination during homogeneous alkyne and allene cyclisation catalysis: Coordination to substrates, to ancillary ligands and in intermediates
title_full_unstemmed Gold coordination during homogeneous alkyne and allene cyclisation catalysis: Coordination to substrates, to ancillary ligands and in intermediates
title_short Gold coordination during homogeneous alkyne and allene cyclisation catalysis: Coordination to substrates, to ancillary ligands and in intermediates
title_sort gold coordination during homogeneous alkyne and allene cyclisation catalysis coordination to substrates to ancillary ligands and in intermediates
topic gold catalysts
gold complex intermediates
homogeneous catalysis
mechanistic studies
organic synthesis
url http://archive.sajs.co.za/index.php/SAJS/article/view/459
work_keys_str_mv AT helgardgraubenheimer goldcoordinationduringhomogeneousalkyneandallenecyclisationcatalysiscoordinationtosubstratestoancillaryligandsandinintermediates
AT hubertschmidbaur goldcoordinationduringhomogeneousalkyneandallenecyclisationcatalysiscoordinationtosubstratestoancillaryligandsandinintermediates