Anti-proliferative effects of T cells expressing a ligand-based chimeric antigen receptor against CD116 on CD34+ cells of juvenile myelomonocytic leukemia

Anti-proliferative effects of T cells expressing a ligand-based chimeric antigen receptor against CD116 on CD34+ cells of juvenile myelomonocytic leukemia

Abstract Background Juvenile myelomonocytic leukemia (JMML) is a fatal, myelodysplastic/myeloproliferative neoplasm of early childhood. Patients with JMML have mutually exclusive genetic abnormalities in granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor (GMR, CD116) signaling pathwa...

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Bibliographic Details
Main Authors: Yozo Nakazawa, Kazuyuki Matsuda, Takashi Kurata, Akane Sueki, Miyuki Tanaka, Kazuo Sakashita, Chihaya Imai, Matthew H. Wilson, Kenichi Koike
Format: Article
Language:English
Published: BMC 2016-03-01
Series:Journal of Hematology & Oncology
Subjects:
Juvenile myelomonocytic leukemia
Chimeric antigen receptor
GM-CSF receptor
Leukemic stem cells
piggyBac transposon
Online Access:http://link.springer.com/article/10.1186/s13045-016-0256-3

Internet

http://link.springer.com/article/10.1186/s13045-016-0256-3

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