MacP bypass variants of Streptococcus pneumoniae PBP2a suggest a conserved mechanism for the activation of bifunctional cell wall synthases

MacP bypass variants of Streptococcus pneumoniae PBP2a suggest a conserved mechanism for the activation of bifunctional cell wall synthases

ABSTRACTThe peptidoglycan (PG) layer protects bacteria from osmotic lysis and defines their shape. The class A penicillin-binding proteins (aPBPs) are PG synthases that possess both glycan polymerization and crosslinking activities needed for PG biogenesis. In Gram-negative bacteria, aPBPs require a...

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Bibliographic Details
Main Authors: Caroline Midonet, Sean Bisset, Irina Shlosman, Felipe Cava, David Z. Rudner, Thomas G. Bernhardt
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:mBio
Subjects:
penicillin-binding proteins
peptidoglycan
cell envelope
cell wall
Online Access:https://journals.asm.org/doi/10.1128/mbio.02390-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02390-23

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