Frequent upregulation of G9a promotes RelB-dependent proliferation and survival in multiple myeloma

Frequent upregulation of G9a promotes RelB-dependent proliferation and survival in multiple myeloma

Abstract Background Multiple myeloma is an incurable hematological malignancy characterized by a heterogeneous genetic and epigenetic landscape. Although a number of genetic aberrations associated with myeloma pathogenesis, progression and prognosis have been well characterized, the role of many epi...

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Main Authors: Xi Yun Zhang, Deepa Rajagopalan, Tae-Hoon Chung, Lissa Hooi, Tan Boon Toh, Johann Shane Tian, Masturah Bte Mohd Abdul Rashid, Noor Rashidha Bte Meera Sahib, Mengjie Gu, Jhin Jieh Lim, Wilson Wang, Wee Joo Chng, Sudhakar Jha, Edward Kai-Hua Chow
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Experimental Hematology & Oncology
Subjects:
Multiple myeloma
G9a
RelB
NF-κB pathway
Proliferation
Tumorigenesis
Online Access:http://link.springer.com/article/10.1186/s40164-020-00164-4

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http://link.springer.com/article/10.1186/s40164-020-00164-4

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