Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas

Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas

Abstract Temozolomide (TMZ) is a standard treatment for glioblastoma (GBM) patients. However, TMZ has moderate therapeutic effects due to chemoresistance of GBM cells through less clarified mechanisms. Here, we demonstrate that TMZ-derived 5-aminoimidazole-4-carboxamide (AICA) is converted to AICA r...

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Bibliographic Details
Main Authors: Jianxing Yin, Xiefeng Wang, Xin Ge, Fangshu Ding, Zhumei Shi, Zehe Ge, Guang Huang, Ningwei Zhao, Dongyin Chen, Junxia Zhang, Sameer Agnihotri, Yuandong Cao, Jing Ji, Fan Lin, Qianghu Wang, Qigang Zhou, Xiuxing Wang, Yongping You, Zhimin Lu, Xu Qian
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41663-2

Internet

https://doi.org/10.1038/s41467-023-41663-2

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