Sustained glymphatic transport and impaired drainage to the nasal cavity observed in multiciliated cell ciliopathies with hydrocephalus

Sustained glymphatic transport and impaired drainage to the nasal cavity observed in multiciliated cell ciliopathies with hydrocephalus

Abstract Background Hydrocephalus (increased ventricular size due to CSF accumulation) is a common finding in human ciliopathies and in mouse models with genetic depletion of the multiciliated cell (MCC) cilia machinery. However, the contribution of MCC to CSF dynamics and, the mechanism by which im...

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Bibliographic Details
Main Authors: Yuechuan Xue, Zachary Gursky, Brittany Monte, Sunil Koundal, Xiaodan Liu, Hedok Lee, Tatyana V. Michurina, Kennelia A. Mellanson, Lucy Zhao, Alice Nemajerova, Kristopher T. Kahle, Ken-Ichi Takemaru, Grigori Enikolopov, Natalia I. Peunova, Helene Benveniste
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Fluids and Barriers of the CNS
Subjects:
Ciliopathy
Multiciliated cell
Hydrocephalus
CEP164
p73
Mouse model
Online Access:https://doi.org/10.1186/s12987-022-00319-x

Internet

https://doi.org/10.1186/s12987-022-00319-x

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