The Large Ectodomain of APP Prevents APP from being Directly Cleaved by γ-Secretase
Background: Alzheimer’s disease (AD) is characterized by the deposition of amyloid-β peptide (Aβ) in the brain. Aβ is produced by sequential β- and γ-secretase cleavages of amyloid precursor protein (APP). Clinical trials targeting β- and γ-secretases have all failed, partly because of the strong si...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2024-02-01
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| Series: | Frontiers in Bioscience-Landmark |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBL/29/2/10.31083/j.fbl2902078 |