Leishmania infantum Parasites Subvert the Host Inflammatory Response through the Adenosine A2A Receptor to Promote the Establishment of Infection

Leishmania infantum Parasites Subvert the Host Inflammatory Response through the Adenosine A2A Receptor to Promote the Establishment of Infection

Adenosine is an endogenously released purine nucleoside that signals through four widely expressed G protein-coupled receptors: A1, A2A, A2B, and A3. Of these, A2AR is recognized as mediating major adenosine anti-inflammatory activity. During cutaneous leishmaniasis, adenosine induces immunosuppress...

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Bibliographic Details
Main Authors: Mikhael H. F. Lima, Lais A. Sacramento, Gustavo F. S. Quirino, Marcela D. Ferreira, Luciana Benevides, Alynne K. M. Santana, Fernando Q. Cunha, Roque P. Almeida, João S. Silva, Vanessa Carregaro
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Immunology
Subjects:
visceral leishmaniasis
adenosine
immunoregulation
A2AR signaling
inflammation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00815/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00815/full

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