Red Blood Cell Peroxynitrite Causes Endothelial Dysfunction in Type 2 Diabetes Mellitus via Arginase

Red Blood Cell Peroxynitrite Causes Endothelial Dysfunction in Type 2 Diabetes Mellitus via Arginase

We recently showed that red blood cells (RBCs) from patients with type 2 diabetes mellitus (T2DM-RBCs) induce endothelial dysfunction through a mechanism involving arginase I and reactive oxygen species. Peroxynitrite is known to activate arginase in endothelial cells. Whether peroxynitrite regulate...

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Bibliographic Details
Main Authors: Ali Mahdi, John Tengbom, Michael Alvarsson, Bernhard Wernly, Zhichao Zhou, John Pernow
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
arginase
endothelial dysfunction
type 2 diabetes
red blood cells
Online Access:https://www.mdpi.com/2073-4409/9/7/1712

Internet

https://www.mdpi.com/2073-4409/9/7/1712

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