Characterization of human translesion DNA synthesis across a UV-induced DNA lesion

Characterization of human translesion DNA synthesis across a UV-induced DNA lesion

Translesion DNA synthesis (TLS) during S-phase uses specialized TLS DNA polymerases to replicate a DNA lesion, allowing stringent DNA synthesis to resume beyond the offending damage. Human TLS involves the conjugation of ubiquitin to PCNA clamps encircling damaged DNA and the role of this post-trans...

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Bibliographic Details
Main Authors: Mark Hedglin, Binod Pandey, Stephen J Benkovic
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-10-01
Series:eLife
Subjects:
DNA damage tolerance
translesion DNA Synthesis
polymerase switching
PCNA monoubiquitination
DNA polymerase eta
DNA polymerase delta
Online Access:https://elifesciences.org/articles/19788

Internet

https://elifesciences.org/articles/19788

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