Re-Evaluations of Zr-DFO Complex Coordination Chemistry for the Estimation of Radiochemical Yields and Chelator-to-Antibody Ratios of <sup>89</sup>Zr Immune-PET Tracers

Re-Evaluations of Zr-DFO Complex Coordination Chemistry for the Estimation of Radiochemical Yields and Chelator-to-Antibody Ratios of <sup>89</sup>Zr Immune-PET Tracers

(1) Background: Deferoxamine B (DFO) is the most widely used chelator for labeling of zirconium-89 (<sup>89</sup>Zr) to monoclonal antibody (mAb). Despite the remarkable developments of the clinical <sup>89</sup>Zr-immuno-PET, chemical species and stability constants of the Z...

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Bibliographic Details
Main Authors: Ryota Imura, Hiroyuki Ida, Ichiro Sasaki, Noriko S. Ishioka, Shigeki Watanabe
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
<sup>89</sup>Zr
immune-PET
deferoxamine
Zr-DFO complex
antibody labeling
coordination chemistry
Online Access:https://www.mdpi.com/1420-3049/26/16/4977

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https://www.mdpi.com/1420-3049/26/16/4977

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