Characterization of a novel zebrafish model of SPEG-related centronuclear myopathy

Characterization of a novel zebrafish model of SPEG-related centronuclear myopathy

Centronuclear myopathy (CNM) is a congenital neuromuscular disorder caused by pathogenic variation in genes associated with membrane trafficking and excitation–contraction coupling (ECC). Bi-allelic autosomal-recessive mutations in striated muscle enriched protein kinase (SPEG) account for a subset...

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Bibliographic Details
Main Authors: Karla G. Espinosa, Salma Geissah, Linda Groom, Jonathan Volpatti, Ian C. Scott, Robert T. Dirksen, Mo Zhao, James J. Dowling
Format: Article
Language:English
Published: The Company of Biologists 2022-05-01
Series:Disease Models & Mechanisms
Subjects:
centronuclear myopathy
disease model
excitation–contraction coupling
muscle
speg
zebrafish
Online Access:http://dmm.biologists.org/content/15/5/dmm049437

Internet

http://dmm.biologists.org/content/15/5/dmm049437

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