A Selective Competitive Inhibitor of Aldehyde Dehydrogenase 1A3 Hinders Cancer Cell Growth, Invasiveness and Stemness In Vitro

A Selective Competitive Inhibitor of Aldehyde Dehydrogenase 1A3 Hinders Cancer Cell Growth, Invasiveness and Stemness In Vitro

Aldehyde dehydrogenase 1A3 (ALDH1A3) belongs to an enzymatic superfamily composed by 19 different isoforms, with a scavenger role, involved in the oxidation of a plethora of aldehydes to the respective carboxylic acids, through a NAD+-dependent reaction. Previous clinical studies highlighted the hig...

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Bibliographic Details
Main Authors: Edoardo L. M. Gelardi, Giorgia Colombo, Francesca Picarazzi, Davide M. Ferraris, Andrea Mangione, Giovanni Petrarolo, Eleonora Aronica, Menico Rizzi, Mattia Mori, Concettina La Motta, Silvia Garavaglia
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
aldehyde dehydrogenases
cancer therapy
cancer stem cells
target validation
glioblastoma
biochemistry
Online Access:https://www.mdpi.com/2072-6694/13/2/356

Internet

https://www.mdpi.com/2072-6694/13/2/356

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