Translating a Thin-Film Rehydration Method to Microfluidics for the Preparation of a SARS-CoV-2 DNA Vaccine: When Manufacturing Method Matters

Translating a Thin-Film Rehydration Method to Microfluidics for the Preparation of a SARS-CoV-2 DNA Vaccine: When Manufacturing Method Matters

Previous investigations conducted on a liposomal formulation for a SARS-CoV-2 DNA vaccine manufactured using the thin-film layer rehydration method showed promising immunogenicity results in mice. The adaptation of the liposomal formulation to a scalable and reproducible method of manufacture is nec...

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Bibliographic Details
Main Authors: Allegra Peletta, Eakachai Prompetchara, Kittipan Tharakhet, Papatsara Kaewpang, Supranee Buranapraditkun, Nongnaphat Yostrerat, Suwimon Manopwisedjaroen, Arunee Thitithanyanont, Jonathan Avaro, Leonard Krupnik, Antonia Neels, Kiat Ruxrungtham, Chutitorn Ketloy, Gerrit Borchard
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Pharmaceutics
Subjects:
DNA vaccines
delivery systems
liposomes
microfluidics
thin-film layer rehydration
manufacturing method
Online Access:https://www.mdpi.com/1999-4923/14/7/1427

Internet

https://www.mdpi.com/1999-4923/14/7/1427

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