Gamma Irradiation-Inactivated Respiratory Syncytial Virus Vaccine Provides Protection but Exacerbates Pulmonary Inflammation by Switching from Prefusion to Postfusion F Protein

Gamma Irradiation-Inactivated Respiratory Syncytial Virus Vaccine Provides Protection but Exacerbates Pulmonary Inflammation by Switching from Prefusion to Postfusion F Protein

ABSTRACT Respiratory syncytial virus (RSV) is a common respiratory pathogen that causes lower respiratory diseases among infants and elderly people. Moreover, formalin-inactivated RSV (FI-RSV) vaccine induces serious enhanced respiratory disease (ERD). Radiation has been investigated as an alternati...

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Bibliographic Details
Main Authors: Fengjia Chen, Hae-Ran Park, Hyun Jung Ji, Yeongkag Kwon, Min-Kyu Kim, Joon Young Song, Ki Bum Ahn, Ho Seong Seo
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:Microbiology Spectrum
Subjects:
respiratory syncytial virus
enhanced respiratory disease
inactivated vaccine
gamma irradiation inactivation
prefusion F
postfusion F
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01358-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.01358-23

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