Loss of Flocculus Purkinje Cell Firing Precision Leads to Impaired Gaze Stabilization in a Mouse Model of Spinocerebellar Ataxia Type 6 (SCA6)

Loss of Flocculus Purkinje Cell Firing Precision Leads to Impaired Gaze Stabilization in a Mouse Model of Spinocerebellar Ataxia Type 6 (SCA6)

Spinocerebellar Ataxia Type 6 (SCA6) is a mid-life onset neurodegenerative disease characterized by progressive ataxia, dysarthria, and eye movement impairment. This autosomal dominant disease is caused by the expansion of a CAG repeat tract in the <i>CACNA1A</i> gene that encodes the α1...

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Bibliographic Details
Main Authors: Hui Ho Vanessa Chang, Anna A. Cook, Alanna J. Watt, Kathleen E. Cullen
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
spinocerebellar ataxia type 6
vestibuloocular reflex
motor learning
eye movements
optokinetic reflex
saccades
Online Access:https://www.mdpi.com/2073-4409/11/17/2739

Internet

https://www.mdpi.com/2073-4409/11/17/2739

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