Rational design of GDP‑d‑mannose mannosyl hydrolase for microbial l‑fucose production

Rational design of GDP‑d‑mannose mannosyl hydrolase for microbial l‑fucose production

Abstract Background l‑Fucose is a rare sugar that has beneficial biological activities, and its industrial production is mainly achieved with brown algae through acidic/enzymatic fucoidan hydrolysis and a cumbersome purification process. Fucoidan is synthesized through the condensation of a key subs...

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Bibliographic Details
Main Authors: Cong Fu, Xuexia Xu, Yukang Xie, Yufei Liu, Min Liu, Ai Chen, Jenny M. Blamey, Jiping Shi, Suwen Zhao, Junsong Sun
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Microbial Cell Factories
Subjects:
l‑Fucose
Bacillus subtilis
GDP‑mannose mannosyl hydrolase
GDP‑l‑fucose
Molecular modeling
Microbial production
Online Access:https://doi.org/10.1186/s12934-023-02060-y

Internet

https://doi.org/10.1186/s12934-023-02060-y

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