Alzheimer’s disease and progressive supranuclear palsy share similar transcriptomic changes in distinct brain regions

Alzheimer’s disease and progressive supranuclear palsy share similar transcriptomic changes in distinct brain regions

Vast numbers of differentially expressed genes and perturbed networks have been identified in Alzheimer’s disease (AD), however, neither disease nor brain region specificity of these transcriptome alterations has been explored. Using RNA-Seq data from 231 temporal cortex and 224 cerebellum samples f...

Full description

Bibliographic Details
Main Authors: Xue Wang, Mariet Allen, Özkan İş, Joseph S. Reddy, Frederick Q. Tutor-New, Monica Castanedes Casey, Minerva M. Carrasquillo, Stephanie R. Oatman, Yuhao Min, Yan W. Asmann, Cory Funk, Thuy Nguyen, Charlotte C.G. Ho, Kimberly G. Malphrus, Nicholas T. Seyfried, Allan I. Levey, Steven G. Younkin, Melissa E. Murray, Dennis W. Dickson, Nathan D. Price, Todd E. Golde, Nilüfer Ertekin-Taner
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-01-01
Series:The Journal of Clinical Investigation
Subjects:
Aging
Neuroscience
Online Access:https://doi.org/10.1172/JCI149904

Internet

https://doi.org/10.1172/JCI149904

Similar Items