HDAC6 Negatively Regulates miR-155-5p Expression to Elicit Proliferation by Targeting RHEB in Microvascular Endothelial Cells under Mechanical Unloading

HDAC6 Negatively Regulates miR-155-5p Expression to Elicit Proliferation by Targeting RHEB in Microvascular Endothelial Cells under Mechanical Unloading

Mechanical unloading contributes to significant cardiovascular deconditioning. Endothelial dysfunction in the sites of microcirculation may be one of the causes of the cardiovascular degeneration induced by unloading, but the detailed mechanism is still unclear. Here, we first demonstrated that mech...

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Bibliographic Details
Main Authors: Liqun Xu, Lijun Zhang, Xiaoyan Zhang, Gaozhi Li, Yixuan Wang, Jingjing Dong, Honghui Wang, Zebing Hu, Xinsheng Cao, Shu Zhang, Fei Shi
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
mechanical unloading
HDAC6
miR-155-5p
RHEB
proliferation
Online Access:https://www.mdpi.com/1422-0067/22/19/10527

Internet

https://www.mdpi.com/1422-0067/22/19/10527

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