Label-free measurement of antimicrobial peptide interactions with lipid vesicles and nanodiscs using microscale thermophoresis

Abstract One strategy to combat antimicrobial resistance is the discovery of new classes of antibiotics. Most antibiotics will at some point interact with the bacterial membrane to either interfere with its integrity or to cross it. Reliable and efficient tools for determining the dissociation const...

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Bibliographic Details
Main Authors: Philip Rainsford, Fredrik G. Rylandsholm, Martin Jakubec, Mitchell Silk, Eric Juskewitz, Johanna U. Ericson, John-Sigurd Svendsen, Richard A. Engh, Johan Isaksson
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-39785-0