FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma

FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma

Summary: Despite the undisputable role of the small GTPase Rac1 in the regulation of actin cytoskeleton reorganization, the Rac guanine-nucleotide exchange factors (Rac-GEFs) involved in Rac1-mediated motility and invasion in human lung adenocarcinoma cells remain largely unknown. Here, we identify...

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Bibliographic Details
Main Authors: Mariana Cooke, Gabriel Kreider-Letterman, Martin J. Baker, Suli Zhang, Neil T. Sullivan, Evgeniy Eruslanov, Martin C. Abba, Silvia M. Goicoechea, Rafael García-Mata, Marcelo G. Kazanietz
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Cell Reports
Subjects:
Rac1
Rac-GEF
EGFR
lung cancer
AXL
FARP1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721013759

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http://www.sciencedirect.com/science/article/pii/S2211124721013759

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