Direct cysteine sulfenylation drives activation of the Src kinase

Direct cysteine sulfenylation drives activation of the Src kinase

The activity of several protein kinases is increased upon cellular production of reactive oxygen species, which can cause cysteine oxidation. Here the authors show that sulfenylation of specific cysteine residues within Src induce local structural changes that directly impact its activation.

Bibliographic Details
Main Authors: David E. Heppner, Christopher M. Dustin, Chenyi Liao, Milena Hristova, Carmen Veith, Andrew C. Little, Bethany A. Ahlers, Sheryl L. White, Bin Deng, Ying-Wai Lam, Jianing Li, Albert van der Vliet
Format: Article
Language:English
Published: Nature Portfolio 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06790-1

Internet

https://doi.org/10.1038/s41467-018-06790-1

Similar Items