A VHH-Based Anti-MUC1 Chimeric Antigen Receptor For Specific Retargeting Of Human Primary T Cells To MUC1-Positive Cancer Cells

A VHH-Based Anti-MUC1 Chimeric Antigen Receptor For Specific Retargeting Of Human Primary T Cells To MUC1-Positive Cancer Cells

Objective: Immunotherapy with redirected T cells that express a chimeric antigen receptor (CAR) is a promising prospect in cancer treatment. Most CARs use murine-derived single-chain variable fragments (scFvs) as an antigen targeting moiety, which may lead to host immunogenic responses and enginee...

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Bibliographic Details
Main Authors: Alireza Rajabzadeh, Fatemeh Rahbarizadeh, Davoud Ahmadvand, Maryam Kabir Salmani, Amir Ali Hamidieh
Format: Article
Language:English
Published: Royan Institute (ACECR), Tehran 2021-01-01
Series:Cell Journal
Subjects:
immunotherapy
single-chain antibodies
t-lymphocytes
Online Access:https://celljournal.org/journal/article/fulltext/a-novel-vhh-based-anti-muc1-chimeric-antigen-receptor-for-specific-retargeting-human-primary-t-cells-to-muc1-positive-cancer-cells.pdf

Internet

https://celljournal.org/journal/article/fulltext/a-novel-vhh-based-anti-muc1-chimeric-antigen-receptor-for-specific-retargeting-human-primary-t-cells-to-muc1-positive-cancer-cells.pdf

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