EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth
EGFR signalling is required for oncogenic Ras driven tumorigenesis. In this study, using aDrosophilatumour model the authors demonstrate that depletion of Arf6, a Ras-related GTP-binding protein activated by EGFR, supresses oncogenic Ras driven overgrowth via modulation of Hedgehog signalling.
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14688 |