Conformational Changes in a Macrolide Antibiotic Binding Protein From Mycobacterium smegmatis Upon ADP Binding

Conformational Changes in a Macrolide Antibiotic Binding Protein From Mycobacterium smegmatis Upon ADP Binding

Rv3197 (MABP-1), a non-canonical ABC protein in Mycobacterium tuberculosis, has ATPase activity and confers inducible resistance to the macrolide family of antibiotics. Here we have shown that MSMEG_1954, the homolog of Rv3197 in M. smegmatis, has a similar function of conferring macrolide resistanc...

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Bibliographic Details
Main Authors: Qingqing Zhang, Xiang Liu, Huijuan Liu, Bingjie Zhang, Haitao Yang, Kaixia Mi, Luke W. Guddat, Zihe Rao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Microbiology
Subjects:
crystal structure
conformational change
macrolide antibiotic binding protein (MABP)
non-canonical ABC transporter
macrolide antibiotic
erythromycin
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.780954/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2021.780954/full

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