Synthesis and Biological Evaluation of Octahydroquinazolinones as Phospholipase A2, and Protease Inhibitors: Experimental and Theoretical Exploration

Synthesis and Biological Evaluation of Octahydroquinazolinones as Phospholipase A2, and Protease Inhibitors: Experimental and Theoretical Exploration

Phospholipase A2 (PLA2) promotes inflammation via lipid mediators and releases arachidonic acid (AA), and these enzymes have been found to be elevated in a variety of diseases, including rheumatoid arthritis, sepsis, and atherosclerosis. The mobilization of AA by PLA2 and subsequent synthesis of pro...

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Bibliographic Details
Main Authors: Md. Afroz Bakht, Thangaiyan Pooventhiran, Renjith Thomas, Mehnaz Kamal, Israf Ud Din, Najeeb Ur Rehman, Imtiaz Ali, Noushin Ajmal, Mohamed Jawed Ahsan
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Molecules
Subjects:
octahydroquinazolinone
phospholipase A2
protease activity
DFT study
molecular docking
Online Access:https://www.mdpi.com/1420-3049/28/4/1944

Internet

https://www.mdpi.com/1420-3049/28/4/1944

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