Hsp90 Inhibitor STA9090 induced VPS35 related extracellular vesicle release and metastasis in hepatocellular carcinoma

Hsp90 Inhibitor STA9090 induced VPS35 related extracellular vesicle release and metastasis in hepatocellular carcinoma

Heat shock protein 90 (Hsp90) has been an important therapeutic target for cancer therapy for decades. Unexpectedly, the monotherapy of N-terminal Hsp90 inhibitor STA9090 related clinical trials halted in phase III, and metastases were reported in animal models with the treatment of N-terminal Hsp90...

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Bibliographic Details
Main Authors: Wenchong Tan, Jinxin Zhang, Lixia Liu, Manfeng Liang, Jieyou Li, Zihao Deng, Zhenming Zheng, Yaotang Deng, Chenyang Liu, Yan Li, Guantai Xie, Jiajie Zhang, Fei Zou, Xuemei Chen
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Translational Oncology
Subjects:
Ganetespib (STA9090)
Extracellular vesicles (EVs)
Vacuolar protein sorting-associated protein 35 (VPS35)
Bcl-2 associated transcription factor 1 (Bclaf1)
Metastasis
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523322001619

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http://www.sciencedirect.com/science/article/pii/S1936523322001619

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