Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation

Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation

Abstract Interleukin-27 is a pleiotropic cytokine whose functions during bacterial infections remain controversial, and its role in patients with S. aureus osteomyelitis is unknown. To address this knowledge gap, we completed a clinical study and observed elevated serum IL-27 levels (20-fold higher,...

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Bibliographic Details
Main Authors: Yugo Morita, Motoo Saito, Javier Rangel-Moreno, Anthony M. Franchini, John R. Owen, John C. Martinez, John L. Daiss, Karen L. de Mesy Bentley, Stephen L. Kates, Edward M. Schwarz, Gowrishankar Muthukrishnan
Format: Article
Language:English
Published: Nature Publishing Group 2022-08-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-022-00228-7

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https://doi.org/10.1038/s41413-022-00228-7

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