Tofacitinib Decreases Autophagy of Fibroblast-Like Synoviocytes From Rheumatoid Arthritis Patients

Tofacitinib Decreases Autophagy of Fibroblast-Like Synoviocytes From Rheumatoid Arthritis Patients

The pathway of Janus tyrosine kinases (JAKs) has a central role in the pathogenesis of Rheumatoid Arthritis (RA) by regulating multiple immune functions and cytokine production. The JAK inhibitor tofacitinib is effective in RA patients not responding to methotrexate or TNF-inhibitors. Since hyperact...

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Bibliographic Details
Main Authors: M. Vomero, M. Caliste, C. Barbati, M. Speziali, A. I. Celia, F. Ucci, C. Ciancarella, E. Putro, T. Colasanti, G. Buoncuore, E. Corsiero, M. Bombardieri, F. R. Spinelli, F. Ceccarelli, F. Conti, C. Alessandri
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
Rheumatoid arthritis
tofacitinib
janus tyrosine kinases
autophagy
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.852802/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.852802/full

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