A Cellular Assay for Spike/ACE2 Fusion: Quantification of Fusion-Inhibitory Antibodies after COVID-19 and Vaccination

A Cellular Assay for Spike/ACE2 Fusion: Quantification of Fusion-Inhibitory Antibodies after COVID-19 and Vaccination

Not all antibodies against SARS-CoV-2 inhibit viral entry, and hence, infection. Neutralizing antibodies are more likely to reflect real immunity; however, certain tests investigate protein/protein interaction rather than the fusion event. Viral and pseudoviral entry assays detect functionally activ...

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Bibliographic Details
Main Authors: Fabien Abdul, Pascale Ribaux, Aurélie Caillon, Astrid Malézieux-Picard, Virginie Prendki, Nathalie Vernaz, Nikolay Zhukovsky, Flavien Delhaes, Karl-Heinz Krause, Olivier Preynat-Seauve
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Viruses
Subjects:
SARS-CoV-2
cell fusion
dual-split luciferase
neutralizing antibody
Online Access:https://www.mdpi.com/1999-4915/14/10/2118

Internet

https://www.mdpi.com/1999-4915/14/10/2118

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