Identification of Novel Pathways Regulated by APE1/Ref-1 in Human Retinal Endothelial Cells

Identification of Novel Pathways Regulated by APE1/Ref-1 in Human Retinal Endothelial Cells

APE1/Ref-1 (apurinic/apyrimidinic endonuclease 1, APE1 or APEX1; redox factor-1, Ref-1) is a dual-functional enzyme with crucial roles in DNA repair, reduction/oxidation (redox) signaling, and RNA processing and metabolism. The redox function of Ref-1 regulates several transcription factors, such as...

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Bibliographic Details
Main Authors: Mahmut Mijit, Sheng Liu, Kamakshi Sishtla, Gabriella D. Hartman, Jun Wan, Timothy W. Corson, Mark R. Kelley
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
APE1/Ref-1
redox signaling
angiogenesis
inflammation
gene expression
ocular diseases
Online Access:https://www.mdpi.com/1422-0067/24/2/1101

Internet

https://www.mdpi.com/1422-0067/24/2/1101

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