Toward the Relevance of Platelet Subpopulations for Transfusion Medicine
Circulating platelets consist of subpopulations with different age, maturation state and size. In this review, we address the association between platelet size and platelet function and summarize the current knowledge on platelet subpopulations including reticulated platelets, procoagulant platelets...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2018-02-01
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Series: | Frontiers in Medicine |
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Online Access: | http://journal.frontiersin.org/article/10.3389/fmed.2018.00017/full |
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author | Stefan Handtke Leif Steil Andreas Greinacher Thomas Thiele |
author_facet | Stefan Handtke Leif Steil Andreas Greinacher Thomas Thiele |
author_sort | Stefan Handtke |
collection | DOAJ |
description | Circulating platelets consist of subpopulations with different age, maturation state and size. In this review, we address the association between platelet size and platelet function and summarize the current knowledge on platelet subpopulations including reticulated platelets, procoagulant platelets and platelets exposing signals to mediate their clearance. Thereby, we emphasize the impact of platelet turnover as an important condition for platelet production in vivo. Understanding of the features that characterize platelet subpopulations is very relevant for the methods of platelet concentrate production, which may enrich or deplete particular platelet subpopulations. Moreover, the concept of platelet size being associated with platelet function may be attractive for transfusion medicine as it holds the perspective to separate platelet subpopulations with specific functional capabilities. |
first_indexed | 2024-04-12T21:50:30Z |
format | Article |
id | doaj.art-225fa1c70006400ebddf878e6aec35da |
institution | Directory Open Access Journal |
issn | 2296-858X |
language | English |
last_indexed | 2024-04-12T21:50:30Z |
publishDate | 2018-02-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Medicine |
spelling | doaj.art-225fa1c70006400ebddf878e6aec35da2022-12-22T03:15:30ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2018-02-01510.3389/fmed.2018.00017338838Toward the Relevance of Platelet Subpopulations for Transfusion MedicineStefan Handtke0Leif Steil1Andreas Greinacher2Thomas Thiele3Institut für Immunologie und Transfusionsmedizin, Greifswald, GermanyInterfakultäres Institut für Funktionelle Genomforschung, Greifswald, GermanyInstitut für Immunologie und Transfusionsmedizin, Greifswald, GermanyInstitut für Immunologie und Transfusionsmedizin, Greifswald, GermanyCirculating platelets consist of subpopulations with different age, maturation state and size. In this review, we address the association between platelet size and platelet function and summarize the current knowledge on platelet subpopulations including reticulated platelets, procoagulant platelets and platelets exposing signals to mediate their clearance. Thereby, we emphasize the impact of platelet turnover as an important condition for platelet production in vivo. Understanding of the features that characterize platelet subpopulations is very relevant for the methods of platelet concentrate production, which may enrich or deplete particular platelet subpopulations. Moreover, the concept of platelet size being associated with platelet function may be attractive for transfusion medicine as it holds the perspective to separate platelet subpopulations with specific functional capabilities.http://journal.frontiersin.org/article/10.3389/fmed.2018.00017/fullplatelet subpopulationplatelet sizeplatelet turnoverplatelet clearanceplatelet maturation |
spellingShingle | Stefan Handtke Leif Steil Andreas Greinacher Thomas Thiele Toward the Relevance of Platelet Subpopulations for Transfusion Medicine Frontiers in Medicine platelet subpopulation platelet size platelet turnover platelet clearance platelet maturation |
title | Toward the Relevance of Platelet Subpopulations for Transfusion Medicine |
title_full | Toward the Relevance of Platelet Subpopulations for Transfusion Medicine |
title_fullStr | Toward the Relevance of Platelet Subpopulations for Transfusion Medicine |
title_full_unstemmed | Toward the Relevance of Platelet Subpopulations for Transfusion Medicine |
title_short | Toward the Relevance of Platelet Subpopulations for Transfusion Medicine |
title_sort | toward the relevance of platelet subpopulations for transfusion medicine |
topic | platelet subpopulation platelet size platelet turnover platelet clearance platelet maturation |
url | http://journal.frontiersin.org/article/10.3389/fmed.2018.00017/full |
work_keys_str_mv | AT stefanhandtke towardtherelevanceofplateletsubpopulationsfortransfusionmedicine AT leifsteil towardtherelevanceofplateletsubpopulationsfortransfusionmedicine AT andreasgreinacher towardtherelevanceofplateletsubpopulationsfortransfusionmedicine AT thomasthiele towardtherelevanceofplateletsubpopulationsfortransfusionmedicine |