Toward the Relevance of Platelet Subpopulations for Transfusion Medicine

Circulating platelets consist of subpopulations with different age, maturation state and size. In this review, we address the association between platelet size and platelet function and summarize the current knowledge on platelet subpopulations including reticulated platelets, procoagulant platelets...

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Main Authors: Stefan Handtke, Leif Steil, Andreas Greinacher, Thomas Thiele
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Medicine
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fmed.2018.00017/full
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author Stefan Handtke
Leif Steil
Andreas Greinacher
Thomas Thiele
author_facet Stefan Handtke
Leif Steil
Andreas Greinacher
Thomas Thiele
author_sort Stefan Handtke
collection DOAJ
description Circulating platelets consist of subpopulations with different age, maturation state and size. In this review, we address the association between platelet size and platelet function and summarize the current knowledge on platelet subpopulations including reticulated platelets, procoagulant platelets and platelets exposing signals to mediate their clearance. Thereby, we emphasize the impact of platelet turnover as an important condition for platelet production in vivo. Understanding of the features that characterize platelet subpopulations is very relevant for the methods of platelet concentrate production, which may enrich or deplete particular platelet subpopulations. Moreover, the concept of platelet size being associated with platelet function may be attractive for transfusion medicine as it holds the perspective to separate platelet subpopulations with specific functional capabilities.
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spelling doaj.art-225fa1c70006400ebddf878e6aec35da2022-12-22T03:15:30ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2018-02-01510.3389/fmed.2018.00017338838Toward the Relevance of Platelet Subpopulations for Transfusion MedicineStefan Handtke0Leif Steil1Andreas Greinacher2Thomas Thiele3Institut für Immunologie und Transfusionsmedizin, Greifswald, GermanyInterfakultäres Institut für Funktionelle Genomforschung, Greifswald, GermanyInstitut für Immunologie und Transfusionsmedizin, Greifswald, GermanyInstitut für Immunologie und Transfusionsmedizin, Greifswald, GermanyCirculating platelets consist of subpopulations with different age, maturation state and size. In this review, we address the association between platelet size and platelet function and summarize the current knowledge on platelet subpopulations including reticulated platelets, procoagulant platelets and platelets exposing signals to mediate their clearance. Thereby, we emphasize the impact of platelet turnover as an important condition for platelet production in vivo. Understanding of the features that characterize platelet subpopulations is very relevant for the methods of platelet concentrate production, which may enrich or deplete particular platelet subpopulations. Moreover, the concept of platelet size being associated with platelet function may be attractive for transfusion medicine as it holds the perspective to separate platelet subpopulations with specific functional capabilities.http://journal.frontiersin.org/article/10.3389/fmed.2018.00017/fullplatelet subpopulationplatelet sizeplatelet turnoverplatelet clearanceplatelet maturation
spellingShingle Stefan Handtke
Leif Steil
Andreas Greinacher
Thomas Thiele
Toward the Relevance of Platelet Subpopulations for Transfusion Medicine
Frontiers in Medicine
platelet subpopulation
platelet size
platelet turnover
platelet clearance
platelet maturation
title Toward the Relevance of Platelet Subpopulations for Transfusion Medicine
title_full Toward the Relevance of Platelet Subpopulations for Transfusion Medicine
title_fullStr Toward the Relevance of Platelet Subpopulations for Transfusion Medicine
title_full_unstemmed Toward the Relevance of Platelet Subpopulations for Transfusion Medicine
title_short Toward the Relevance of Platelet Subpopulations for Transfusion Medicine
title_sort toward the relevance of platelet subpopulations for transfusion medicine
topic platelet subpopulation
platelet size
platelet turnover
platelet clearance
platelet maturation
url http://journal.frontiersin.org/article/10.3389/fmed.2018.00017/full
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AT leifsteil towardtherelevanceofplateletsubpopulationsfortransfusionmedicine
AT andreasgreinacher towardtherelevanceofplateletsubpopulationsfortransfusionmedicine
AT thomasthiele towardtherelevanceofplateletsubpopulationsfortransfusionmedicine