Concerted transformation of a hyper-paused transcription complex and its reinforcing protein

Concerted transformation of a hyper-paused transcription complex and its reinforcing protein

Abstract RfaH, a paralog of the universally conserved NusG, binds to RNA polymerases (RNAP) and ribosomes to activate expression of virulence genes. In free, autoinhibited RfaH, an α-helical KOW domain sequesters the RNAP-binding site. Upon recruitment to RNAP paused at an ops site, KOW is released...

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Bibliographic Details
Main Authors: Philipp K. Zuber, Nelly Said, Tarek Hilal, Bing Wang, Bernhard Loll, Jorge González-Higueras, César A. Ramírez-Sarmiento, Georgiy A. Belogurov, Irina Artsimovitch, Markus C. Wahl, Stefan H. Knauer
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47368-4

Internet

https://doi.org/10.1038/s41467-024-47368-4

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